Feb 13, 2020 · As a diagnostic criteria of HCC, the exact threshold of Alpha-fetoprotein (AFP) is controversial. Therefore, this study was aimed to systematically estimate the performance of AFP in diagnosing HCC and to clarify its optimal threshold.

Alpha-fetoprotein (AFP), an oncofetal glycoprotein normally expressed in fetus, is currently the most widely used tumor marker for HCC. Its cellular function in adult humans still remains to be determined. In healthy adults, serum AFP level typically falls into the range of 5–10 ng/mL [7].

Alpha-fetoprotein (AFP) is an oncofetal glycoprotein that has been used as a tumor marker for hepatocellular carcinoma (HCC) in combination with ultrasound and other imaging modalities. Its utility is limited because of both low sensitivity and ...

May 4, 2023 · Alpha-fetoprotein (AFP) is an important plasma protein synthesized by the yolk sac and fetal liver. In adults, its main utility is as a tumor marker, primarily for hepatocellular carcinoma or teratoma. Functionally it is the fetal homologue of albumin, i.e. it acts as a major carrier protein in the antenatal circulation. It is encoded by the ...

Alpha-fetoprotein (AFP) was first described in 1953 as a fetal form of albumin and as a marker for HCC [1 – 3], which opened up the relationship between oncogenesis and embryogenesis. Since then, it has become the best-described and most used marker in HCC.

Feb 13, 2020 · Hepatocellular carcinoma (HCC) has become a pressing health problem facing the world today due to its high morbidity, high mortality, and late discovery. As a diagnostic criteria of HCC, the exact threshold of Alpha-fetoprotein (AFP) is controversial.

This review summarizes the most relevant studies associated with the regulation of AFP at the gene and protein levels; the pathophysiology of AFP as a pro-proliferative protein; and the correlation of AFP with molecular HCC subclasses, the vascular endothelial growth factor pathway and angiogenesis.

Jul 1, 2023 · Alpha fetoprotein (AFP) is the most widely used tumor marker for hepatocellular carcinoma (HCC). Nevertheless, few studies have investigated the prognostic factors of HCC patients with normal serum AFP levels.

Aug 22, 2019 · Alpha-fetoprotein (AFP) is the most widely accepted serum biomarker used in the management of hepatocellular carcinoma (HCC). The regulation and pathophysiology of AFP informs the basis for its clinical relevance in the context of HCC.

Oct 19, 2019 · Introduction: serum alpha-fetoprotein (AFP) was routinely employed as a tumor marker for screening, diagnosis, and treatment follow-up of hepatocellular carcinoma (HCC). However, a substantial proportion of HCC patients had normal AFP level even at …