The MCI-Park mice are compound mutant (Ndufs2fl/fl; DAT IREScre/+) animals in which Ndufs2, a gene encoding a core subunit of the mitochondrial respiratory chain, is selectively inactivated in ...

This interactive resource organizes decades of data on biomarkers for Alzheimer's disease. Biomarker measurements from the cerebrospinal fluid and blood are curated from the primary literature and ...

When Alois Alzheimer described the case of Auguste D. to an audience of fellow psychiatrists in Tuebingen, Germany, in 1906, what set her case apart was the fact that her dementia appeared before she ...

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This brain bank, biobank, and biospecimen bank derives its donors from the Arizona Study of Aging and Neurodegenerative Disease (AZSAND), a longitudinal clinicopathological study of elderly volunteers ...

At a young age, this transgenic mouse develops severe motor impairment and other ALS-related phenotypes. Notably, it develops robust neuronal loss in the spinal cord, denervation of neuromuscular ...

As biomarker testing becomes more common in Alzheimer’s research, scientists face the tricky question of whether to disclose results. In studies of hypothetical scenarios, including a recent survey ...

First trial of concurrent amyloid and tau immunotherapies in sporadic Alzheimer’s is underway. Safety data are a go for subcutaneous remternetug. Plaque removal correlates with cognitive benefit in ...

Perhaps our most defining characteristic as a species, the six-layered human cortex, hosts billions of neural connections that bestow Homo sapiens with higher-order thinking. But how does this ...

Because hypertension is linked to a greater risk of dementia, several trials have investigated whether lowering blood pressure in older people would protect the brain. Data from cohorts of a few ...

Cells, are you experiencing stress? Quick, SUMOylate your TDP-43 before it’s too late! Three independent papers appearing in rapid succession deliver the same message: Chain the small ubiquitin-like ...

At the AD/PD meeting held last month in Vienna, scientists implicated T lymphocytes—specifically, the cytotoxic, CD8-positive variety—in Alzheimer’s disease. While the modus operandi of these cells in ...