Introduction and objectives Inhalers are widely used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). For patients to gain maximum benefit they need to be educated by ...

Rationale Chronic obstructive pulmonary disease (COPD) is associated with systemic inflammation and cardiovascular disease. Interaction between inflammatory cells and activated platelets is important ...

Introduction Identifying acute hypercapnic respiratory failure is crucial in the initial management of acute exacerbations of COPD. Guidelines recommend obtaining arterial blood samples but these are ...

This review examines the rationale for increased study of the prenatal development of airway smooth muscle (ASM). With a critical role in asthma and airway remodelling, ASM has been extensively ...

BACKGROUND: Many patients with chronic obstructive lung disease show increased airways responsiveness to histamine. We investigated the hypothesis that increased airways responsiveness predicts the ...

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3 Centre for Clinical Epidemiology, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada Correspondence to Dr Pierre Ernst, Centre for Clinical Epidemiology, ...

Background Owing to discrepancies in methodologies and how idiopathic pulmonary fibrosis (IPF) is diagnosed it is challenging to establish a consistent understanding of the disease burden In the UK, ...

1 Royal Brompton & Harefield Hospitals, Guy’s and St.Thomas’ NHS Foundation Trust, London, UK Since the Guideline, there is deeper understanding of referral characteristics, outcome measures, patient ...

Background: A systematic review was undertaken to evaluate the efficacy of tiotropium, a long acting anticholinergic drug, on clinical events, symptom scales, pulmonary function, and adverse events in ...

Professor T K Lim, Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074; mdclimtk{at}nus.edu.sg ...

Correspondence to Dr Serenydd Everden, Department of Respiratory Medicine, Royal Berkshire NHS Foundation Trust, Reading RG1 5AN, UK; serenydd.everden{at}googlemail.com A 57-year-old man with no ...