Background Previous natural history studies highlighted a consistent heterogeneity of disability trajectories among ...

Correspondence to Dr Satoshi Kuwabara, Department of Neurology, Graduate School of Medicine, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8670, Japan; kuwabara-s{at}faculty.chiba-u.jp ...

Apathy is increasingly recognised as a common behavioural syndrome in psychiatric disorders, but it is conceptually ill defined. The aim of this study was to examine the concept of apathy as it is ...

Objective: To determine the pattern of motor neurone loss in amyotrophic lateral sclerosis (ALS). In particular, to determine whether there is a gradual life long presymptomatic motor neurone loss or, ...

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Faculty of Medicine MS/MRI Research Group, University of British Columbia, Vancouver, Canada Helen Tremlett, PhD, Department of Medicine (Neurology), rm S178, 2211 Wesbrook Mall, University of British ...

1 Department of Clinical Neurology, The Royal Hallamshire Hospital, Sheffield, UK 2 Department of Gastroenterology, The Royal Hallamshire Hospital Correspondence to: Dr M Hadjivassiliou, Department of ...

Background MRI-guided focused ultrasound (MRgFUS) thalamotomy is a promising non-invasive treatment option for medication-resistant essential tremor. However, it has been associated with variable ...

Institute of Clinical Neurosciences, University of Sydney, Sydney, NSW 2006, Australia Professor John D Pollard, Institute of Clinical Neurosciences, University of Sydney, NSW 2006, Australia ...

OBJECTIVES To evaluate the influences of chronic alcohol consumption on brain volume among social drinkers, as it is well known that alcohol misusers have a high risk of brain shrinkage. METHODS ...

Dr JL Iddon, Department of Academic Neurosurgery, Box 167, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 5RG, UK email jo.iddon{at}cenes.co.uk OBJECTIVES Eleven patients ...

Objectives: Bilateral chronic high frequency stimulation of the subthalamic nucleus (STN), through the stereotactical placement of stimulating electrodes, effectively improves the motor symptoms of ...