TFIID enables RNA polymerase II promoter-proximal pausing. Mol Cell 2020, 78: 785 – 793. Schier, AC; Taatjes, DJ. Structure and mechanism of the RNA polymerase II transcription machinery. Genes Dev.

An RNA polymerase II molecule is about 15 nanometers across, or roughly 5,000 times smaller than the width of a human hair. This image was created by reconstructing X-ray diffraction crystallography ...

These insights from researchers could have major implications for diseases like cancer, where gene expression goes awry.

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

Chromatin structure allows activators to associate ... result of TFs that govern the way genes are transcribed and RNA polymerase II is recruited. Through these mechanisms, TFs control important ...

In DNA, two complementary strands of nucleotides pair up through hydrogen bonds between the bases (A with T and G with C) to form the iconic double helix structure ... RNA through the process of ...

The enzyme RNA polymerase attaches to the DNA in a non ... Peptide bonds form between the adjacent amino acids to finalise the structure.

In the study, published today in Science, the researchers discovered that the amount of a specific enzyme, RNA Polymerase II (RNAPII), found ... due to their unique structure, meaning these ...