News

Applied DNA Reschedules Intra-Quarter Webcast and Investor Update Call to June 17
STONY BROOK, NY / ACCESS Newswire / May 29, 2025 / Applied DNA Sciences, Inc. (NASDAQ:APDN) (“Applied DNA” or the “Company”), ...
AHA/ASA Journals10d
Disruption of cTnT-Mediated Sarcomere–Mitochondrial Communication Results in Dilated Cardiomyopathy
BACKGROUND: Dilated cardiomyopathy (DCM) is substantially influenced by genetic factors. Sarcomere function is intricately associated with other organelles, particularly the reciprocal regulation ...
The EMBO Journal8mon
NS2 induces an influenza A RNA polymerase hexamer and acts as a transcription to replication switch
The structure of the full-length NS2 as part of the FluPol ... activity of FluAPol absolutely relies on its interaction with the CTD of human RNA polymerase II (Pol II) to enable cap snatching, we ...
PNAS1y
Chromatin regulates alternative polyadenylation via the RNA polymerase II elongation rate
The RNA polymerase II (Pol II) elongation rate influences poly(A ... sequence-specific effects on Pol II pausing and/or the local chromatin structure might underlie why FACT- and Spt6-depleted cells ...
News Medical1y
RNA Polymerase Types and Roles in Eukaryotes
RNAP II is the enzyme primarily responsible for the synthesis of messenger RNA (mRNA). RNAP I and III contain an extra heterodimeric subunit. RNAP III alone has a heterotrimeric subunit ...
eLife2y
Genetic dissection of the RNA polymerase II transcription cycle
How DNA sequence affects the dynamics and position of RNA Polymerase II (Pol II ... where alternative termination altered mRNA primary structure. These findings suggest that changes in Pol II ...
eLife3y
Mitotically heritable, RNA polymerase II-independent H3K4 dimethylation stimulates INO1 transcriptional memory
This phenomenon, called epigenetic transcriptional memory, accelerates reactivation, and requires both changes in chromatin structure and recruitment of poised RNA polymerase II (RNAPII) to the ...
C&EN3y
How transcription gets its start, in pictures
RNA polymerase II, or Pol II, doesn’t start working on ... But getting to a clear structure of the entire complex was far from a given: it was considered too big, too floppy, too unstable.
Frontiers4y
Regulation of RNA Polymerase II Transcription Initiation and Elongation by Transcription Factor TFII-I
United Kingdom Transcription by RNA polymerase II (Pol II) is regulated by different processes, including alterations in chromatin structure, interactions between distal regulatory elements and ...
The New York Times5y
Bad News Wrapped in Protein: Inside the Coronavirus Genome
Viruses must hijack living cells to replicate and spread. When the coronavirus finds a suitable cell, it injects a strand of RNA that contains the entire coronavirus genome. The genome of the new ...
Frontiers6y
RNA Polymerase II-Dependent Transcription Initiated by Selectivity Factor 1: A Central Mechanism Used by MLL Fusion Proteins in Leukemic Transformation
In eukaryotes, RNA is polymerized by three distinct RNA polymerases, RNA polymerase I, II, and III (RNAP1 ... the transcription of previously-transcribed MLL target genes. Structure/function analysis ...