Somatic hypermutation (SHM) of immunoglobulin variable (V) regions modulates antibody-antigen affinity is initiated by activation-induced cytidine deaminase (AID) on single-stranded DNA (ssDNA).

This manuscript characterizes a mutated clone of RNA polymerase I in yeast, referred to as SuperPol, to understand the mechanisms of RNA polymerase I elongation and termination. The authors present ...

We have previously demonstrated that the protein encoded by the retinoblastoma susceptibility gene (Rb) functions as a regulator of transcription by RNA polymerase ... or (ii) the binding of ...

RNA polymerase II holoenzymes respond to activators and repressors that are regulated by signaling pathways. Here we present evidence for a “shortcut” mechanism in which the Snf1 protein kinase of the ...

Contribution from the Laboratory of Molecular Biophysics, Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, and Laboratory of Synthetic Protein Chemistry, The Rockefeller University, New York ...