View Full Profile. Learn about our Editorial Policies. Rational design is the classical protein engineering method that involves site directed mutagenesis. 7 Scientists perform specific point ...

Functional protein design, particularly for proteins binding to small molecules such as enzymes and biosensors, is crucial for drug discovery and biomedical applications. Traditional methods based ...

LigandMPNN is a deep-learning-based protein sequence design method that can explicitly model all nonprotein components of biomolecular systems. Protein nanocages are multimeric molecular ...

AI systems already work their magic in many areas of biomedical science, helping to solve protein structure, discover hidden ...

In living organisms, every protein—a type of biological polymer consisting of hundreds of amino acids—carries out specific ...

While AlphaFold and the subsequent AI revolution in biology garnered a lot of attention, the foundational bricks for the strides made in protein structure and design today were laid ... we could use ...

A new set of artificial intelligence models could make protein sequencing even more powerful for better understanding cell biology and diseases.

However, existing methods have significant limitations—they often apply only to a narrow range of proteins, require genetic modifications, or risk damaging protein function due to nonspecific ...

Shanghai scientists have made breakthrough in protein design by leveraging artificial intelligence, establishing the world's ...

Scientists in Shanghai have made a breakthrough in protein design by leveraging artificial intelligence, establishing the ...

In this method, the cell extract or culture medium is passed through a chromatography column filled with a porous carrier material. The target protein is bound to this carrier material and ...

Like the other Nature titles, Nature Methods has no external editorial ... where she studied de novo protein receptor design and investigated protein-ligand interactions using NMR spectroscopy.