Researchers at the Max Planck Institute for Evolutionary Anthropology have addressed a longstanding challenge in CRISPR ...

However, many mammalian transcription factors function differently at divergent complex eukaryotic promoters, in some cases acting as either an activator or repressor, depending on the context.

Here we asked how genetic modifications shape the dose–response curve of biosensors based on metabolite-responsive transcription factors. Using the lac system in Escherichia coli as a model system, we ...

Scanning of the mRNA transcript by the preinitiation complex (PIC) requires a panel of eukaryotic initiation factors, which includes eIF1 and eIF1A, the main transducers of stringent AUG selection.

Transcriptional activation of the interferon‐β (IFN‐β) gene requires assembly of an enhanceosome containing the transcription factors ATF‐2/c‐Jun, IRF‐3/IRF‐7, NF‐κB and HMGI(Y). These factors ...

Discussion: This study lays the groundwork for further exploration of the molecular mechanisms and functional validation of WRKY transcription factors in A. lancea. Fresh plant tissues from 3-year-old ...

A study published in the journal Cell marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells.

Consistently, Suv39h1 silencing restored expression of contractile genes and attenuated proliferation/migration in VSMCs exposed to PDGF (platelet-derived growth factor)-BB ... by activating Jag1 ...

This is an important study utilizing innovative CRISPR based approaches demonstrating the role of the KLF family of transcription factors in the post natal maturation of cortical projection neurons.