However, many mammalian transcription factors function differently at divergent complex eukaryotic promoters, in some cases acting as either an activator or repressor, depending on the context.

The course focuses on current understanding of the structure and function of eukaryotic transcription factors. The aim of the first general part is to give the student an understanding of the main ...

A new study published in Nature reveals how olfactory sensory neurons (OSNs) achieve extraordinary precision in selecting ...

Researchers at the Max Planck Institute for Evolutionary Anthropology have addressed a longstanding challenge in CRISPR ...

Several genetic studies have attempted to explore the fungal factors involved in antiviral responses, but the exact genes and ...

When the workload on the heart increases, the ventricular wall may thicken too, known as cardiac hypertrophy. This is an adaptive response that reduces pressure on the heart and maintains the activity ...

Osteogenic differentiation is essential for bone development, metabolism, and repair; however, the underlying regulatory relationships among genes remain poorly understood. To elucidate the ...

ACVR2A downregulation disrupts the TCF7/c-JUN pathway, impairing trophoblast invasion and proliferation in pre-eclampsia, revealing a genetic susceptibility-associated mechanism of placental ...

Reshma Bano is a postdoctoral research fellow at the Department of Physics, University of Surrey. She earned her PhD in ...

Transcriptional activation of the interferon‐β (IFN‐β) gene requires assembly of an enhanceosome containing the transcription factors ATF‐2/c‐Jun, IRF‐3/IRF‐7, NF‐κB and HMGI(Y). These factors ...

Here we asked how genetic modifications shape the dose–response curve of biosensors based on metabolite-responsive transcription factors. Using the lac system in Escherichia coli as a model system, we ...