Since zinc fingers are typically linked together to recognize longer DNA stretches, the team assembled them into arrays, creating new junctions between the individual zinc finger units.

The aim of this paper is to study how the zinc-finger proteins that recruit KAP1 to the genome evolve to recognize and target new inherited retroviruses.

Zinc fingers might be the answer to that seemingly insurmountable challenge. Historically, however, viruses have been the only viable mechanism for faulty gene repair (let's call it gene therapy).

These zinc finger pair interactions influence DNA binding and hence gene expression. The machine learning model developed by Kim and his group mirrors the data synthesis approach in the Noyes lab.

Zinc-finger nucleases are synthetic "designer" proteins combining a zinc-finger domain, engineered to bind a particular DNA sequence, with an enzyme that breaks both DNA strands at the targeted site.

"Zinc finger" gene therapy tackles the toxic tangles of Alzheimer's. An artist's depiction of amyloid plaques surrounded by tau tangles, both considered key pathological signs of Alzheimer's disease .

Novartis and Sangamo are developing a particular version of the technology called zinc finger protein transcription factors (ZFP-TFs), in which the zinc fingers direct an artificial transcription ...

But zinc fingers were hard to engineer — for every new DNA target, scientists had to engineer a new protein through a laborious and often unsuccessful workflow.

Zinc-finger gene editing has been in development since the mid-1990s and it's already being evaluated in human clinical trials. Will Zinc-finger technology result in breakthrough treatments that ...

Since zinc fingers are typically linked together to recognize longer DNA stretches, the team assembled them into arrays, creating new junctions between the individual zinc finger units.