Y2H is a genetic method that relies on the modular architecture of transcriptional activators to identify protein-protein interactions in the yeast nucleus. At first, researchers used Y2H mainly to ...

Fred Chang, PhD, MD, uses a Confocal microscope to view a yeast cell with an oversized nucleus. Photo by Barbara Ries Using fission yeast as a model organism, his lab explores fundamental aspects of ...

By anchoring transcription factors (and the genes they regulate) to nuclear pore proteins, Exportin-1 helps reposition genes to the edge of the nucleus. This relocation ... Arts & Sciences has mainly ...

Read the paper: Overlapping nuclear import and export paths unveiled by two-colour MINFLUX In organisms that have cells with a nucleus, DNA is stored in this compartment, which is surrounded by a ...

In addition to exporting materials out of the nucleus, the protein ... Northwestern's Weinberg College of Arts & Sciences has mainly focused on yeast, an organism he says is "an excellent model ...