Y2H is a genetic method that relies on the modular architecture of transcriptional activators to identify protein-protein interactions in the yeast nucleus. At first, researchers used Y2H mainly to ...

The findings advance our understanding of how genes are regulated in fission yeast but could also reveal ... positioning of certain genes within the nucleus—a finding that could provide a ...

Left, fission yeast; right, budding yeast; visualized with the nuclear DNA stain DAPI (4',6-diamidino-2-phenylindole) to highlight the nucleus. The Domino and Clock Models of Cell Cycle Regulation ...

However, the yeast two-hybrid system is limited to studying proteins that can translocate to the nucleus and do not display any autonomous capacity for activating transcription 2. Thus ...

This valuable study focuses on defining how the HSP70 chaperone system utilizes J-domain proteins to regulate the heat shock response-associated transcription factor HSF1. Using a combination of ...

"All cells that have a nucleus also house a variety of organelles ... In a previous study, Mehta's team showed that lab-generated cyanobacteria-yeast chimeras, or endosymbionts, can supply ...