Meiotic errors in oocytes cause egg aneuploidy. This study shows that kinetochores employ MPS1 kinase to promote timely ...

Epigenetic changes do not alter the genetic code itself, but by changing how DNA is organized within the cell, epigenetic ...

This valuable study examines the role of E2 ubiquitin enzyme, Uev1a in tissue resistance to oncogenic RasV12 in Drosophila melanogaster polyploid germline cells and human cancer cell lines. The ...

Large-scale comparison of gene families across 1154 Saccharomycotina genomes revealed that gene gains and losses drive yeast ...

The yeast nuclear endonuclease Rnt1 has a well-characterized role in the maturation of many ncRNA precursors. However, the scope and consequence of its function in mRNA degradation pathways is much ...

But with increasingly efficient and cheaper DNA reading and synthesis technologies, the goal isn’t beyond reach. Similar techniques could also inspire other projects to redesign chromosomes in ...

The large consortium has the objective of synthesizing all 16 natural chromosomes of the baker's yeast Saccharomyces cerevisiae and then combining them to form a completely synthetic cell. The ...

Although bacterial and viral chromosomes have been synthesized ... reached the end of the beginning—the complete synthesis of a synthetic yeast genome," said lead author, Yu Zhao, PhD, a ...

"Assembling all yeast chromosomes from the ground up is a monumental ... globally has reached the end of the beginning-the complete synthesis of a synthetic yeast genome," said lead author ...