Unveiling the intricate mechanisms behind oxysterol-induced cell death
Oxysterols are a class of molecules derived from cholesterol via oxidation or as byproducts of cholesterol synthesis. Despite ...
Unraveling structure and function relationships in synthetic cell receptors
Northwestern University researchers have identified structural features in engineered cell receptors that correlate with ...
The Harvard Crimson1d
The 16,000 Generation Yeast
Michael M. Desai, Professor of Organismic and Evolutionary Biology and of Physics, hopes to leverage the common fungus to ...
eLife2d
SATAY-based chemogenomic screening uncovers antifungal resistance mechanisms and key determinants of ATI-2307 and chitosan sensitivity
This important manuscript proposes a new strategy for the identification of new mechanisms of drug resistance based on SAturated Transposon Analysis in Yeast (SATAY), a powerful transposon sequencing ...
eLife3d
High-Resolution Genome-Wide Maps Reveal Widespread Presence of Torsional Insulation
Torsional stress in chromatin plays a fundamental role in cellular functions, influencing key processes such as transcription, replication, and chromatin organization. Transcription and other ...