Wolverine was poisoned and this ties into the initial threat from the opening. Someone is hunting down adamantium. This also plays into the trope of taking out a heavy hitter early in order to ...

Hunting caused the species to disappear from ... Despite recent population growth, the wolverine's survival remains threatened by its small population size, low genetic viability, and fragmented ...

It’s a simple story, with each issue focusing on Wolverine hunting down his foes, and it’s all the better for it.