To overcome the challenges of the existing model systems, researchers developed organoids, which are 3D multicellular structures. Organoids contain multiple organ-specific cell types interacting with ...

The model suggests that changes in the volume of intestinal cells and lumen—the fluid-filled cavity inside gut organoids—play a crucial role in modulating the mechanical forces within the tissue.

When mice with liver injuries received organoid tissue transplants, more of those receiving the multizonal versions (MZ ...

One reason why our livers excel at clearing waste from our blood system is that the organ functions according to three key ...

Karl Koehler builds inner ear and skin organoids from human stem cells to model their development in health and disease.

While organoids aim to mimic human organs, the liver's repertoire of complex functions – and thus the energy it needs to operate – have made it challenging for researchers to grow organoids ...

"The photoreceptor cells within human organoids can respond to light and communicate with each other through synaptic connections," says Gamm. "To determine whether they can connect inside a ...

These organoids provide scientists with better models for studying liver biology, and for developing treatments for various liver disorders.

When mice with liver injuries received organoid tissue transplants, those receiving multizonal versions (MZ organoids) survived longer than mice receiving either zone 3-only or Zone 1-only versions.