Extracellular vesicles play a vital role in cell biology, modulating communication and signaling, with potential applications in diagnostics and therapeutics.

More than half of patients with ischemic stroke experience futile reperfusion, increasing the risk of death and disabilities despite a successful recanalization. The reason behind this is debated, and ...

State Key Laboratory of Membrane Biology, Institute of Molecular Medicine, National Biomedical Imaging Center, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future ...

These toxins block exocytosis (the process of secretion, involving fusion of the transport vesicle with the plasma membrane) by proteolysis of one or another of the presynaptic SNARE molecules ...

The calcium dependence of vesicle exocytosis at synapses is a power law with an exponent n = 3 or 4, however, the molecular mechanisms that underpin this highly non-linear dependence on calcium are ...

Gene ontology (GO) analysis demonstrated that the upregulated proteins in EE mice were primarily related to biological processes of synaptic vesicle transport and exocytosis. The GO terms for these ...

Neuronal communication and brain function mainly depend on the fundamental biological events of neurotransmission, including the exocytosis of presynaptic vesicles (SVs) for neurotransmitter release ...

Neurotransmitter release is mediated by the fast, calcium-triggered fusion of synaptic vesicles with the presynaptic plasma ... either up- or downregulated upon triggering calcium-dependent exocytosis ...

Synaptic vesicles release neurotransmitter by following a process of vesicle docking and exocytosis. Although these steps are well established, it has been difficult to observe and measure these rates ...