Here, we expand the repertoire of PROTAC compatible E3 ligases by identifying a novel small molecule scaffold targeting the ubiquitin E3 ligase KLHDC2 using a fluorescence polarization-based high ...

NASA has identified a glitch in the propulsion system of its Psyche spacecraft which is on its way to explore a metal rich asteroid of the same name. In a blog post published last week, NASA revealed ...

Treatment with an mTOR inhibitor in 6-month-old TRGL/Q175 mice normalized lysosome numbers, alleviated aggresome pathology, and reduced mHTT, p62, and ubiquitin levels ... and also commented on its ...

Here, we highlight the contributions of these published works and place them into the broader context of ubiquitin biology and its clinical implications ... the authors reveal that the ...

Toward the end of March, OpenAI said it intended to release its first “open” language model since GPT‑2 sometime this year. Now, details about that model are beginning to trickle out from ...

Most municipalities today set their own local waste collection tax rates (known as the TARI), while recently a few have moved to a “pay-as-you-throw system,” with fees based on the amount of ...

Our system is wringing every penny out of hard working families to pay for care… even PM agreed it’s wrong Features More ‘His timing was impeccable’: How a NI family rose to eminence in ...

Department of Biochemistry and Biophysics, College of Agriculture and Life Sciences, Texas A&M University, College Station, Texas 77843, United States ...

China has released an action plan to promote the use of the yuan and its own payment system in international trade, as it seeks to reduce its dependence on the dollar amid an escalating trade war ...

Hyundai Motor Group has unveiled its next-generation hybrid powertrain system. Revealed at the company's 'Next-Gen Hybrid System Tech Day', the new configuration includes critical mechanical and ...