Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Sciences, Oncological Sciences and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York ...

Taken together, these findings demonstrate that interferon triggers PARP14-mediated ADP-ribosylation in p62 bodies, which requires an active ubiquitin-proteasome ... prompting us to explore the ...

The FGF15/FGFR4/ERK signaling pathway was notably activated in the skeletal muscle tissues of nobiletin-supplemented mice, suggesting a protective effect against muscle atrophy despite the pathway’s ...

The work has led to a new class of therapeutic targets associated with the ubiquitin-proteasome pathway that offers the potential for treatment of cachexia (also known as muscle atrophy) and other ...

The memorandum directs all DOD components to adopt the Software Acquisition Pathway (SWP) as the preferred acquisition method for all software development components of business and weapon system ...

On Saturday, March 22, Morrison, 52, was arrested in Palm Beach, Fla. following alleged simple battery in an incident that took place at Le Bar à Vin. According to the probable cause affidavit ...

This process involves two main pathways: the ubiquitin-proteasome system for intracellular proteins and the lysosomal proteolysis pathway, which degrades extracellular proteins and cell surface ...

The non-structural protein nsp16 of SARS-CoV-2 was identified that can be degraded through the proteasome pathway. A. The non-structural proteins ... MARCHF7 and UBR5 were identified as E3 ubiquitin ...

Alzheimer’s disease (AD) is the most common cause of age-related dementia leading to severe irreversible cognitive decline and massive neurodegeneration. While therapeutic approaches for managing ...