A major pathway for protein degradation is initiated by the addition of multiple 76–amino acid ubiquitin monomers via a three-step process of ubiquitin activation and substrate recognition.

A communications breakdown between two biochemical pathways is involved in causing cataracts in mice, scientists have discovered. The newfound relationship between the ubiquitin and calpain ...

Afu Fu, Victoria Cohen-Kaplan, Noa Avni, Ido Livneh, Aaron Ciechanover, p62-containing, proteolytically active nuclear condensates, increase the efficiency of the ubiquitin–proteasome system, ...

A new editorial paper was published in Oncoscience (Volume 11) on May 6, 2024, entitled, "Restoring our ubiquitination machinery to overcome resistance in cancer therapy." ...

Proteasome collaborate with ubiquitin to degrade proteins. [Love Employee/Getty Images] Newly Identified Proteasomal Protein Disposal Mechanism Bypasses Ubiquitin Tagging. August 24, 2023.

Time for the Ubiquitin-Proteasome System #3 These papers look very interesting and show the relevance in Alzheimer disease of an efficient working protein quality control by the ubiquitin-proteasome ...

Proteins bearing C-terminal amides (CTAPs), a chemical modification caused by oxidative stress, are rapidly cleared from cells, they report. This occurs through interactions with the protein FBXO31.

Critical cellular processes are regulated, in part, by maintaining the appropriate intracellular levels of proteins. Whereas de novo protein synthesis is a comparatively slow process, proteins are ...