Cells maintain a continuous free pool of ubiquitin that can be conjugated onto target proteins to mark them for degradation by the proteasome. Now, in Cell, Finley and colleagues show that the ...

We believe that the ubiquitin/proteasome pathway is involved in so many cellular processes that it could not be properly described by a single model substrate and that the minimal requirement ...

PROTACs are small molecules that use the ubiquitin-proteasome system to remove unwanted proteins. They are a promising class of cancer-fighting drugs, but there are challenges with getting them ...