Here, we will review principles of ubiquitin‐dependent control of gene expression and discuss how breakdown of these regulatory circuits leads to a wide array of human diseases.

Current protein knockdown approaches, such as proteolysis-targeting chimeras (PROTACs), have limitations in their applications to the proteins degraded through proteasome-independent ways. Here, we ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

The aim of the present study was to examine the effects of calpain inhibitor I in rats subjected to experimental colitis. METHODS Colitis was induced in rats by intracolonic instillation of ...

† Lab of Meat Processing and Quality Control of EDU, College of Food Science and Technology, Synergetic Innovation Center of Food Safety and Nutrition, Nanjing Agriculture University, Nanjing, Jiangsu ...

We demonstrated that Ror and Rev-erb, two important components of the muscle peripheral clock, are crucial for regulating nocturnal protein clearance via the ubiquitin–proteasome system and autophagy.