The proteasome is a large protein complex in the cytoplasm of eukaryotic and archaeal cells responsible for proteolysis of proteins that have one or more poly-ubiquitin post-translational ...

As the world’s population ages, neurodegenerative diseases are becoming more widely acknowledged as serious global health and socioeconomic issues. Although many resources have been devoted to the ...

The review by Yongmei Wang et al., “The ubiquitin-proteasome system in the tumor immune microenvironment: a key force in combination therapy,” provides a comprehensive analysis of the UPS’s role in ...