Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly ...

Using the cellular ubiquitin-proteasome system (UPS) to alter viral protein stability is a promising strategy for developing live-attenuated vaccines. Researchers first engineered PROTAR influenza ...

PROTACs are small molecules that use the ubiquitin-proteasome system to remove unwanted proteins. They are a promising class of cancer-fighting drugs, but there are challenges with getting them ...

Researchers estimate that about 10 million people globally live with Parkinson’s disease — a neurological condition that affects movement. While the exact cause of Parkinson’s disease is ...

This occurs through interactions with the protein FBXO31. On binding CTAPs, FBXO31 summons a ubiquitin ligase to tag the modified proteins for dismantling by the proteasome. Curiously, loss of FBXO31 ...

In this new editorial, researchers Xiaoling Li and Ping Mu from the University of Southwestern Medical Center discuss the ubiquitin-proteasome system (UPS), which is usually responsible for ...

Triplet or quadruplet therapies incorporating proteasome inhibitors, immunomodulators, and anti-CD38 antibodies have led to prolonged survival among patients with newly diagnosed multiple myeloma ...

While multiple protein degradation pathways exist—including the autophagy-lysosome, calcium-dependent calpain, and cysteine aspartate protease systems—the ubiquitin-proteasome pathway emerges as an ...

“Our findings provide direct evidence that the ubiquitin proteasome system is a crucial player in Alzheimer’s disease. This opens up a plethora of new targets for therapeutic intervention,” Glickman ...