The review by Yongmei Wang et al., “The ubiquitin-proteasome system in the tumor immune microenvironment: a key force in combination therapy,” provides a comprehensive analysis of the UPS’s role in ...

Department of Applied Biosciences, Graduate School of Bioagricultural Science, Nagoya University, Nagoya, Japan In skeletal muscle, calcium is not only essential to stimulate and sustain their ...

New research published in the journal Nature has revealed a previously unknown function of the proteasome, a component of cells once thought to only play a role in the degradation of proteins. A ...

Calcium-activated proteolysis by calpain is a candidate to participate in this form of pathology because it is activated under ischemic conditions and its activation results in the degradation of ...

In the CNS, calpains exist in two major isoforms: µ-calpain (or calpain-I) and m-calpain (or calpain-II). To determine whether these calpains showed changes in their expression after SCI, we performed ...

The 26S proteasome is responsible for the selective, ATP-dependent degradation of polyubiquitinated cellular proteins. Removal of ubiquitin chains from targeted substrates at the proteasome is a ...