The proteasome is a large protein complex in the cytoplasm of eukaryotic and archaeal cells responsible for proteolysis of proteins that have one or more poly-ubiquitin post-translational ...

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart -- an important process for maintaining heart health.

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health.

We determine the crystal structure of the C-terminal part of IFT172, uncovering a conserved U-box-like domain often found in E3 ubiquitin ligases ... generally function as cofactors that link the ...

Double fluorescence immunolabeling and immuno-electron microscopy (IEM) revealed colocalization of HTT/mHTT with the autophagy-related adaptor proteins, p62/SQSTM1 and ubiquitin, and cathepsin D (CTSD ...

Center for Biomolecular and Cellular Structure, Institute for Basic Science, Daejeon, Republic of Korea Huntington’s disease (HD) is primarily caused by the aberrant aggregation of the N-terminal exon ...

Ubiquitination involves the covalent attachment of the protein ubiquitin to substrates ... and cells were incubated for 24 h. Proteasome inhibitor MG-132 (10 μM, 474790; Millipore-Sigma) was added to ...