Many calpain orthologues in parasites or microorganisms ... than proteases such as caspases and those involved in the ubiquitin–proteasome system. Consequently, the biological functions and ...

The ubiquitin proteasome system (UPS) regulates the ubiquitination, and thus degradation and turnover, of many proteins vital to cellular regulation and function. The UPS comprises a sequential series ...

As the maintenance of protein homeostasis is essential to human health, malfunctions of the ubiquitin-proteasome system (UPS) causes various diseases such as cancers, inflammation, and ...

Polyubiquitination targets proteins for recognition and processing by the 26S proteasome, a cylindrical organelle that recognizes ubiquitinated proteins, degrades the proteins, and recycles ubiquitin.

Found in most known organisms, the proteasome is the crucial component of ubiquitin-mediated protein degradation. It complements the numerous proteases that degrade proteins in the cell. Protease ...

A Complex Role in Cellular Process & Growing Tool Set to Elucidate It It is increasingly clear that the ubiquitin-proteasome-system (UPS) is misnamed. Ubiquitylation is not just about targeting ...

Protein turnover is crucial in maintaining cellular homeostasis and this process is largely controlled by the Ubiquitin Proteasome Pathway (UPP). The pathway consists of an enzymatic cascade that ...

Success as An Anti-Cancer Agent Has Fueled Efforts to Discover Proteasome Inhibitors That Raise Proteins Levels with Beneficial Effects The ubiquitin proteasome system (UPS) provides a mechanism ...

The protein tagged with ubiquitins is referred to as a polyubiquitin chain and this is bound by the proteasome for degradation. This overall process of protein degradation is termed the ubiquitin ...

The big biotech firm Celgene will work with San Francisco-based Nurix to develop small molecules that function through the ubiquitin-proteasome system (UPS) to modulate protein homeostatis.

Protein turnover is crucial in maintaining cellular homeostasis and this process is largely controlled by the Ubiquitin Proteasome Pathway (UPP). The pathway consists of an enzymatic cascade that ...