Scientists at deCODE genetics/Amgen have identified associations between bipolar disorder and rare loss-of-function variants ...

By applying a machine-learning technique called a "self-organizing map," they found 801 new white dwarf-main sequence (WDMS) binaries, increasing the total number ever found by more than 20%.

The team has now published a paper in Optica describing the procedure. In 2DES, a sequence of three ultrashort laser pulses is used to excite the material to be investigated. The first two pulses ...

Spliceosome structures have been investigated extensively in the past decade, but most of the studies have been restricted to a handful of model organisms. New research by Lu et al, looks outside this ...

For example, DELTEX E3 ligases were reported to ubiquitylate a hydroxyl group on free NAD + and ADP-ribose in vitro, generating a noncanonical ubiquitin ester-linked species. In this report, we show, ...

It serves as a molecular ‘rubbish tag’, with long chains of ubiquitin being added onto a protein to earmark it for destruction. This labelling process requires three types of enzymes working in ...

Ubiquitin-mediated proteasomal degradation is a post-transcriptional protein modification that is comprised of various components including the 76-amino acid protein ubiquitin (Ub), Ub-activating ...

UBE3A is an E3 ubiquitin ligase encoded by an imprinted gene whose maternal deletion or duplication leads to distinct neurodevelopment disorders Angelman and Dup15q syndromes. Despite the known ...

It shares a striking sequence similarity to the Hrd1 complex that plays critical ... Our study provides a novel model of achieving multi-tasking for transmembrane ubiquitin ligases with ...

The unfolding behavior of ubiquitin under the influence of a stretching force recently was investigated experimentally by single-molecule constant-force methods. Many observed unfolding traces had a ...