Mar. 13, 2025 — A study shows that high-grade glioma tumor cells harboring DNA alterations in the gene PDGFRA responded to the drug avapritinib, which is already approved by the United States ...

Compass Therapeutics, Inc. (Nasdaq: CMPX), a clinical-stage, oncology-focused biopharmaceutical company developing proprietary antibody-based therapeutics to treat multiple human diseases, today ...

These include modulation of the microvasculature via angiogenesis-targeted agents, induction of a potent immune response via activators on effector cells in the tumor microenvironment, and alleviation ...

The cadherin family, which includes T-cadherin, plays a significant role in angiogenesis, a critical process involved in tumor growth, metastasis, and recurrence. T-cadherin is extensively expressed ...

We also are exploring therapeutic options to block fatty acid accumulation and immunosuppressive signals between the cancer cells and the neutrophils,” said Zhang, William T. Butler, M.D ...

Immunotherapy has emerged as a promising alternative; however, the unique biological and immunological features, including its immunosuppressive tumor microenvironment (TME) and low mutational burden, ...

PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative regulator of the type I interferon (IFN-I) and nuclear receptor signaling, ...

In tumor microenvironments, substances like 8-OHG drive macrophage polarization towards the immunosuppressive M2 type. M1 macrophages, with higher ferritin expression, are more resistant to ...

However, you may have heard some conflicting information about soy and cancer risk. You might have questions like, “Is soy healthy? Is it dangerous? And if it’s OK to eat soy foods, why do some people ...

C.Y. and X.-F.W. wrote the paper. Z.-Z. Wu et al., Erythroid progenitor cell–mediated spleen–tumor interaction deteriorates cancer immunity. Proc. Natl. Acad. Sci ...