Unstable repeats are associated with various types of cancer and have been implicated in more than 40 neurodegenerative disorders. Trinucleotide repeats are located in non-coding and coding ...

DNA trinucleotide repeat expansions are known to be associated with several hereditary neurodegenerative disorders, including Huntington disease, Fragile X syndrome and spinocerebellar ataxia.

Researchers have gained new insight into the genetic mechanisms underlying Huntington's disease and other trinucleotide repeat (TNR) disorders, identifying a novel DNA repair pathway that ...

More information: Zaneta Matuszek et al, Base editing of trinucleotide repeats that cause Huntington's disease and Friedreich's ataxia reduces somatic repeat expansions in patient cells and in ...

University of Kentucky researchers have gained new insight into the genetic mechanisms underlying Huntington's disease and other trinucleotide repeat (TNR) disorders, identifying a novel DNA ...

New research has identified a mechanism in the DNA mismatch repair pathway that stops the abnormal trinucleotide repeat expansion and the progression of Huntington’s disease. Scientists at the ...

In most cases, such diseases are caused by abnormal repeat expansion of three nucleotides, which is why they are known also as trinucleotide repeat disorders," says one of the lead authors of the ...

Additionally, this approach may extend to other trinucleotide repeat disorders caused by similar mechanisms. For example, Spinocerebellar Ataxias , a group of inherited disorders, are caused by ...

In a clinical report issued by the American Academy of Pediatrics and published online June 23 in Pediatrics, guidance is ...

Huntington’s disease and Friedreich’s ataxia are part of a group of neurological disorders dubbed trinucleotide repeat disorders because they are caused by repeating three-letter stretches of DNA.

The conditions are two of more than 40 severe neurological disorders caused by three-letter stretches of DNA that repeat consecutively. If longer than a certain threshold length, these sequences ...