News

Nature1d
Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10
Figure 1: Expansion mutations in four SCA10 families. Figure 4: Correlation between the size of expanded SCA10 ATTCT repeat and the age of onset. Figure 5: Sca10 is widely expressed in brain ...
GEN - Genetic Engineering and Biotechnology News3d
Base Editors Curb Repeating DNA in Huntington’s and Ataxia Models
Early research shows that editing expanding trinucleotide repeats halts the lengthening process that causes neurological ...
Gene editing disrupts Huntington's mutation in mice
Broad Institute researchers have developed a way to edit the genetic sequences at the root of Huntington's disease and ...
BMJ9d
The differential diagnosis of Huntington's disease-like syndromes: ‘red flags’ for the clinician
3 Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology ... to the genetic testing for HD causative mutations, that is, IT15 gene trinucleotide-repeat expansion.
Precision Medicine Online12d
Dyne Reports on Response Predictive Biomarkers for Neurodegenerative Disorder Genetic Medicine
The ASO for myotonic dystrophy type 1 was well tolerated and improved splicing and function in a study presented at ASGCT.
C&EN14d
A Dynamic Structural Model of Expanded RNA CAG Repeats: A Refined X-ray Structure and Computational Investigations Using Molecular Dynamics and Umbrella Sampling Simulations
† Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208, United States § ‡ Translational Research Institute and § Department of ...
C&EN16d
Comparative Study of the Bending Free Energies of C- and G-Based DNA: A-, B-, and Z-DNA and Associated Mismatched Trinucleotide Repeats
Department of Physics, North Carolina State University, Raleigh, North Carolina 27695-8202, United States ...
NPR17d
A promising genetic treatment tailor-made for a baby born with a rare disorder
For the first time, doctors have treated a baby born with a rare, life-threatening genetic disorder with a gene-editing therapy scientists tailored to specifically repair his unique mutation.
USA Today17d
Panthers oust Lightning convincingly: How far can defending NHL champions go?
The defending champion Florida Panthers ousted the Tampa Bay Lightning 6-3 in Game 5, wrapping up a convincing series win that bodes well for their repeat bid. The Panthers, healthy after dealing ...
Brooklyn Daily Eagle17d
Liberty start repeat quest Saturday
Finals MVP Jonquel Jones knows the Liberty’s 2025 season will have its share of ups and downs as the quest to repeat begins Saturday in Downtown Brooklyn. AP Photo by Abbie Parr “We try to ...
CBS News18d
A radar clocked someone going nearly double the speed limit. It turned out to be a duck — and a "repeat offender."
A radar image of a speed offender caught in central Switzerland last month revealed that the culprit was not only a duck, but likely a "repeat offender," local authorities said. Police in the town ...
NPR19d
A quarter of children have a parent with substance use disorder, a study finds
Nearly 19 million children in the United States have at least one parent with a substance use disorder, according to a new study published Monday in JAMA Pediatrics. And a significant number of ...