Early research shows that editing expanding trinucleotide repeats halts the lengthening process that causes neurological disease.

Broad Institute researchers have developed a way to edit the genetic sequences at the root of Huntington's disease and ...

3 Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology ... to the genetic testing for HD causative mutations, that is, IT15 gene trinucleotide-repeat expansion.

SPOKANE, Wash. – Lane Butts, a Spokane resident, is confronting the possibility of inheriting Huntington's disease, a genetic brain disease that affected his mother and grandfather. The ...

"This is a really different way of thinking about how a mutation brings about a disease, and we think that it will apply in DNA-repeat disorders beyond Huntington's disease." "The point of our ...

"The initiation of this fasedienol repeat dose study marks another significant milestone in our U.S. Phase 3 program for the acute treatment of social anxiety disorder,” said Shawn Singh ...

Rumination disorder, or rumination syndrome, is a condition in which someone regularly regurgitates their food after eating it. The food is re-chewed and then either re-swallowed or spat out.

For example, Huntington’s disease (HD), the first expansion disorder discovered, occurs when a cysteine-arginine-guanine (CAG) trinucleotide in the HTT gene swells to 40 or more repeats. Such ...

The work was reported in Cell. Two recent studies have also highlighted the significance of repeat expansion disorders (REDs). There are about fifty disorders that have been linked to tandem repeats.

A new paper published in Cell describes an approach to correct the genetic defect that underlies the neurodevelopmental disorder fragile X syndrome ... FXS is caused by a trinucleotide repeat ...

Summary: Researchers have identified a potential new treatment method for Fragile X Syndrome (FXS), a leading cause of autism spectrum disorders. The method involves contracting the CGG trinucleotide ...

Pervasive developmental disorders (PDD) — now known as autism spectrum disorder (ASD) — refers to a group of conditions that affect average development. It may appear as a delay in development ...