A research team has discovered that the two key pathological hallmarks of Alzheimer's -- tau protein and beta-amyloid -- affect brain circuits in distinct yet synergistic ways, particularly those ...

A research team from the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) has discovered that the two key pathological hallmarks of Alzheimer's-tau protein and beta-amyloid ...

A new study reveals that tau protein affects memory, while beta-amyloid disrupts emotions in Alzheimer’s disease. Using a novel mouse model, researchers found that both proteins interact to worsen ...

A research team from the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) has discovered that the ...

A research team from the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) has discovered that the two key pathological ...

APP 695 SWE mice expressing transgenic human APP with the two-point (Lys 670 →Asn, Met 671 →Leu) 'Swedish' mutation show age-dependent impairments in several histopathological features ...

Here we created an HBV transgenic severe combined immunodeficiency (SCID) mouse that consistently supports HBV gene expression and replication. After adoptive transfer of syngeneic, unprimed ...

Stationed within the meninges, squads of immune cells lie in wait, ready to unleash an inflammatory assault within the brain if needed. Holding these trigger-happy troops back during peacetime falls ...

The genes that build the cartilage of fish gills were repurposed to build the cartilage in mammals’ outer ears ...

2002). In addition to motor neuron loss, these mice also lose superficial cortical neurons. The number of NeuN-positive cortical neurons was comparable to wild-type at 2 months of age, but transgenic ...

“Furthermore, manipulating key microglial receptors by using different transgenic mouse lines resulted in changes in depletion efficacies that were also sex dependent. These findings suggest sex ...