And they give a detailed description of the thymus based on a standardised representation ... to identify the neuron types generated in each organoid and to determine how closely they resembled ...

“Our discovery—the regulatory T cell recirculation back to the thymus—promotes repair through a process that hasn’t been described before and represents a novel pathway to regeneration ...

The team’s study results, published today in the journal Immunity, outline their discovery of a specific type of regulatory T cell that can home back into the thymus and repair the organ when it ...

An innovative organoid model mirrors the pancreas' complexity, generating all three key cell types to explore development and possible regeneration. Laura is an assistant editor for The Scientist. She ...

Image: Organoid or ‘live mini tumours’ of high grade serous ovarian cancer grown in ICR laboratories from samples of cancer cells isolated from patients. These live mini tumours are used for a host of ...

In this review, we discuss recent advances in versatile human tonsil/adenoid tissue-based ex vivo immune organoid cultures as well as related cancer and autoimmunity-focused experimental setups. These ...

The thymus plays a pivotal role in generating a highly-diverse repertoire of T lymphocytes while preventing autoimmunity. Thymus seeding progenitors (TSPs) are a heterogeneous group of multipotent ...

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Furthermore, using a dorsoventral organoid fusion model, Yuan et al. (2020) showed that LHX6 is essential for GABAergic interneuron migration. Another study implanted patient iPSC-derived ventralized ...