News

eLife12h
β-Glucan reprograms alveolar macrophages via neutrophil/IFNγ axis in a murine model of lung injury
Glucan-mediated trained immunity activates alveolar macrophages which exacerbates acute lung injury induced by LPS.
CAR-T cells engineered to attack two leukemia proteins show promise in preclinical tests
T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive form of blood cancer that can occur in both children and ...
News-Medical.Net1d
Study provides a molecular snapshot of Tanshi constitution's immunological landscape
The study aims to uncover the immunological basis of Tanshi (phlegm-dampness) constitution—a subhealth type in traditional ...
EMBO Press1d
Hippo pathway controls biopterin metabolism to shield adjacent cells from ferroptosis in lung cancer
Heterogeneous Hippo pathway (YAP/TAZ) activation in lung adenocarcinoma drives tumor progression by enabling ferroptosis ...
Scientists Turn Forgotten Cells Into Powerful Cancer Killers
Immunologists at UNIGE have revealed a previously unknown anti-tumor role of CD4 T lymphocytes, marking a breakthrough that ...
rmdopen.bmj4d
Integration of transcriptome and immunophenotyping data highlights differences in the pathogenetic kinetics of B cells across immune-mediated disease | RMD Open
Results Patients with IMDs were stratified into two clusters based on their immunophenotypes. Cluster 1 was enriched with differentiated B cells, including unswitched memory B cells (USM B), switched ...
Frontiers4d
Heterologous booster vaccination enhances antibody responses to SARS-CoV-2 by improving Tfh function and increasing B-cell clonotype SHM frequency - Frontiers
Isolated B cells and Tfh cells were cocultured as previously described with minor modifications (23, 24). 3×10^5/well B cells were cultured with or without 1.5×10^5/well Tfh cells in the presence of ...