Both adaptive and innate immunity are affected with age. Thymic involution and inflammation are both related to age-associated immunity. T & B cells in aging The pool of naive cells is reduced ...

A progressive decay of immune system integrity remodels immune function at a basic level. Thymic atrophy, which substantially affects T-cell-dependent immune function, shifts immune response ...

Lymphocytes are white blood cells that have important immune functions. The main populations of lymphocytes are B cells, T cells and natural killer (NK) cells. They are typically (although not ...

Growth hormone (GH) is a classic pituitary-derived hormone crucial to body growth and metabolism. In the pituitary gland, GH production is stimulated by GH-releasing hormone and inhibited by ...

Cancer of the thymus gland is rare. Most cancers that start in the thymus gland are called thymomas. There’s also a much rarer form of thymus gland cancer called thymic carcinoma. The thymus gland is ...

However, age-associated thymic involution and diseases or treatment associated injury result in a decline in its continuous role in the maintenance of T cell-mediated anti-tumor/virus immunity. Acute ...

One of the feats of adaptive immunity is its ability to recognize foreign pathogens while sparing the self. During maturation in the thymus, T cells are selected through the binding properties of ...

Unexpectedly, we discovered that the quiescence of TEC progenitors is a major factor underlying thymus involution. These findings have consequences for targeted thymic regeneration and the ...