The immune system is a very dynamic network, consisting of various innate and adaptive cells acting via direct cell–cell contact, as well as indirect messaging mediated by soluble factors ...

One hypothesis put forward to explain this phenomenon is the involution of the thymus, where T-cell maturation happens (Figure 1). Thymic involution is not only observed in the elderly, but begins ...

However, thymic involution significantly reduces its effectiveness over time. Factors such as stress, infections, and cancer treatments can temporarily shrink the thymus, but research has shown ...

The main thymus gland function is to process and teach your T cells how to identify and get rid of germs and other foreign substances. Your thymus gland is in the upper part of your chest. It sits ...

Tolerance Bio’s technologies aim to delay and prevent thymic involution and restore thymic function if lost, ultimately addressing these immune diseases and potentially increasing longevity.

The thymus is critical for establishing adaptive immunity but undergoes age-related involution, impairing immune function. It is also sensitive to acute damage, and its regenerative ability ...

Credit: Aging Research (2024). DOI: 10.26599/AGR.2024.9340021 Aging significantly impacts the immune system, notably through the involution of the thymus, which reduces T cell production.

Aging significantly impacts the immune system, notably through the involution of the thymus, which reduces T cell production. This decline weakens immune responses, making older adults more ...

The importance of chronic sterile inflammation for ageing pathologies is increasingly recognized and inflammation itself is a central hallmark of ageing. In simplified terms, ageing is associated with ...

The organoid, composed of fibroblasts and thymus derived cells, is capable of generating mature and diverse T cells, including CD4, CD8, and regulatory T cells, in vitro and in vivo.