The thymus functions as the primary lymphoid organ responsible for the generation of T cells and plays a crucial role in preventing autoimmune reactions by eliminating autoreactive cells before ...

Interactions with self-peptide–MHC complexes on thymic epithelial cells are crucial for thymocyte survival (positive selection) and CD4 versus CD8 lineage commitment, but can also result in ...

Objective: In mice, a subpopulation of gut dendritic cells (DCs) expressing CD103 drives the development of regulatory T (Treg) cells. Further, it was recently described that the cross-talk between ...

A model developed by LMU biophysicists demonstrates how biological processes form the convoluted internal architecture of the thymus—allowing for better suppression of autoimmune responses.

Objective UC is a chronic inflammatory disease of the colonic mucosa. Growing evidence supports a role for epithelial cell defects in driving pathology. Moreover, long-lasting changes in the ...

Along this journey, thymocytes encounter various components of the thymic microenvironment, a three-dimensional network formed of thymic epithelial cells (TECs), macrophages, dendritic cells, ...