The thymus functions as the primary lymphoid organ responsible for the generation of T cells and plays a crucial role in preventing autoimmune reactions by eliminating autoreactive cells before ...

The thymus is a crucial training ground for T-cells, the body's "white knights," where they learn to battle the various ...

Thymic epithelial cells are indispensable in the development of T cells but little is known about precursor-progeny relationships between distinct thymic epithelial lineages. In June 17 Advanced ...

RANKL treatment also led to a boon of thymic endothelial and epithelial cells in human cells grown in the lab, which means the compound could be translated to human studies, the authors suggest in ...

By creating the first spatial atlas of the developing human thymus, a vital organ that trains immune cells to protect against infections and cancer, scientists have discovered that the foundation for ...

Researchers at the Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne have discovered new cells that drive the aging process in the thymus that could unlock a way to restore ...

Dudakov and others used bioinformatic techniques, including next generation sequencing, and advanced imaging to detect changes in stem cells, which have the capacity to differentiate into various cell ...

The cells that “mentor” developing T cells are called thymic epithelial cells, or TECs. We know that TECs get replaced by adipose cells as we age, but there’s a lot left to learn about other ...

The researchers were able to show that in the thymus gland of humans and mice not only the epithelial cells but also B cells express and present AQP4 to the T cell precursors.

PT-112 induces immunogenic cell death and stimulates an anti-cancer adaptive immune response. The ongoing Phase 2 clinical trial for thymic epithelial tumors (NCT05104736) is examining the response ...

The goal of the first phase is to make best-in-class human induced pluripotent stem cell-derived thymic epithelial cells (iPS-TECs) to restore T cell development in thymic deficient animals, and ...