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Thymic epithelial cells (TEC) are heterogeneous stromal cells that generate microenvironments required for the formation of T cells within the thymus. Defects in TEC lead to immunodeficiency or ...
The thymus is a crucial training ground for T-cells, the body's "white knights," where they learn to battle the various ...
The thymus functions as the primary lymphoid organ responsible for the generation of T cells and plays a crucial role in preventing autoimmune reactions by eliminating autoreactive cells before ...
Thymic epithelial cells are indispensable in the development of T cells but little is known about precursor-progeny relationships between distinct thymic epithelial lineages. In June 17 Advanced ...
For the first time, scientists at the Francis Crick Institute have pinpointed stem cells within the human thymus, offering a fresh avenue for exploring immune diseases, cancer, and strategies to ...
Medullary thymic epithelial cells (mTECs) allow the thymus to ensure that the body’s T cells are able to distinguish between potentially harmful foreign antigens and those that are produced by ...
The epithelial cells, known as TECs (thymic epithelial cells), are further classified into cTECs (cortical TECs) and mTECs (medulla TECs). Thymic organogenesis is governed by the highly potent ...
The thymus and T cells. T cells are white blood cells. ... These are both known as thymic epithelial tumors (TETs). Thymomas are slower-growing tumors that don't often spread beyond your thymus.
Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus. Developmental Cell , 2023; DOI: 10.1016/j.devcel.2023.08.017 Cite ...
In the results of a paper published March 23 in Stem Cell Reports, they described how they built the organoids, starting by growing thymic epithelial progenitor cells—or TEPs, precursor cells to ...
However, these findings, published today in Developmental Cell, show for the first time the presence of self-renewing stem cells, which give rise to the thymic epithelial cells instructing thymocytes ...
Until now, scientists believed the thymus didn’t contain "true" epithelial stem cells. However, new findings show the presence of self-renewing stem cells, which give rise to the thymic epithelial ...