In this study, we have discovered a new concept of redox pharmacology that focuses on the supersulfidation of cysteine residues (Cys-SnSH; n≥1) to protect protein function using oxidized glutathione ...

fact, it has been observed that perturbations in antioxidant defense systems, and consequently redox imbalance, are present in many tissues of HIV-infected patients. Moreover, there is clear ...

Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong SAR, PR China CAS-HKU Joint Laboratory of Metallomics for Health and Environment, The University of Hong Kong, Pokfulam ...

Human Papillomavirus (HPV) is linked to multiple cancers, most significantly cervical cancer, for which HPV infection is associated with nearly all cases. Essential to the oncogenesis of HPV is the ...

Moreover, depletion of NADPH can also hinder GSH/GSSG conversion ... function and that the Trx system may be an important target for disease intervention and treatment (Bjørklund et al., 2022).

Exposure to toxicants activates a detoxifying system (thiol-containing molecules) through the direct release of metallothioneins, GSH and phytochelatins by granular haemocytes. Exposure to ...

Newly made proteins are unstructured chains of amino acids that must fold into particular shapes to work effectively. Proteins that are destined to be exported from the cell undergo folding in a ...

GSH-mediated vasorelaxation was not different with the control RBCs, but was eliminated when RBCs from βCys93-mutant mice were used, further suggesting a primary role for SNO-Hb and βCys93 in local ...