Here, we expand the repertoire of PROTAC compatible E3 ligases by identifying a novel small molecule scaffold targeting the ubiquitin E3 ligase KLHDC2 using a fluorescence polarization-based high ...

Researchers found that the compound TEMPO can effectively suppress free radical formation and control the dangerous thermal ...

Alma Mater Studiorum-Dipartimento di Chimica “G. Ciamician”, Università di Bologna, Via Gobetti 83, Bologna 40129, Italy Center for Chemical Catalysis - C3, Alma Mater Studiorum, Università di Bologna ...

Abstract: Low-field nuclear magnetic resonance (NMR) is a widely employed technique in geoscience. However, signal-to-noise ratio (SNR) is always an issue in low-field NMR measurement, which should be ...

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo n. 2, Prague 6 16610, Czech Republic Department of Physical and Macromolecular Chemistry, Faculty of ...

1,3-dioxolane ketal of isatin; p-sulfonic acid-calix[n]arene; reusable catalytic system; supramolecular catalysis The exact masses of calix[n]arene compounds were obtained using a Fourier-transform ...

Analyses of metabolic compounds inside cells or tissues provide high information content since they represent the endpoint of biological information flow and are a snapshot of the integration of many ...

Protein arginine methyltransferase 1 (PRMT1) can catalyze the protein arginine methylation by transferring the methyl group from S-adenosyl-L-methionine (SAM) to the guanidyl nitrogen atom of protein ...