A protein folding mystery solved: Study explains core packing fractions
In living organisms, every protein—a type of biological polymer consisting of hundreds of amino acids—carries out specific ...
Rolling Out21d
9 ways peptides are revolutionizing modern medicine
Research in the Journal of Investigative Dermatology demonstrates how specific peptide sequences derived from extracellular matrix proteins can accelerate wound healing by promoting cell migration ...
Frontiers23d
Trends in the research and development of peptide drug conjugates: artificial intelligence aided design
De novo peptide design relies solely on the sequence and/or structural information of target receptors to generate novel binding peptides, based on working mechanisms, this approach can be broadly ...
C&EN23d
SWAPS: A Modular Deep-Learning Empowered Peptide Identity Propagation Framework Beyond Match-Between-Run
Computational Mass Spectrometry, School of Life Sciences, Technical University of Munich, Freising 85354, Germany Chair of Proteomics and Bioanalytics, School of Life Sciences, Technical University of ...
C&EN28d
Spontaneous Formation of a Sustainable Antifreeze Coating by Peptide Self-Assembly
The peptide design is inspired by and combines different elements from distinct natural proteins: (i) a sequence of amino acids from an antifreeze protein and (ii) the amino acids ...
BioSpace1mon
Cell Penetrating Peptide Market Size to Worth USD 9.02 Billion by 2034
Furthermore, machine learning algorithms can be applied for rational designing of primary amino acid sequence from peptide datasets for predicting the penetrative capacity of a sequence which can ...
Frontiers3y
Effect of Different Nuclear Localization Signals on the Subcellular Localization and Anti-HIV-1 Function of the MxB Protein
Tat-HA was cloned into pcDNA3.1 expression vector ... factor that binds to HIV-1 LTR but not other promoters. The N-terminal sequence of MxB possesses the activity of directing protein localization to ...
eLife4y
The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway
Post-translationally modified peptides are involved in many aspects of plant growth ... a post-Golgi compartment by aspartate-dependent subtilase SBT3.8 Addressing the sequence and subcellular sites ...
eLife8y
Mechanistic insight into a peptide hormone signaling complex mediating floral organ abscission
The HAESA co-receptor SERK1, a positive regulator of the floral abscission pathway, allows for high-affinity sensing of the peptide hormone by binding to an Arg-His-Asn motif in IDA. This sequence ...