Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...

Co-recruitment of E2F4 and p53 (wild-type and TAD mutant) is observed on established as well as newly identified DREAM complex targets. Next, we wanted to explore whether the repression of the DREAM ...

This cover highlights the article Multimodal mechanisms of human centriole engagement and disengagement by Kei K. Ito, Shoji Hata, Daiju Kitagawa and colleagues. The cover image depicts the centriole ...

Additionally, analyses of A/B compartments and TAD structures indicated that Ad-p53-host interactions do not disrupt the higher-order chromatin architecture of the host genome. These findings provide ...

In our study, using monocytes isolated from four AH patients and 4 healthy controls, we in fact see significant changes in chromatin conformation caused by disease. Interestingly, we did not find ...

with decreased chromatin accessibility (lower ATAC-seq signals) flanking (within ±30 kb) the stable, gained or lost TAD boundaries (Figures 2C, 3C), which have not been reported so far and maybe ...

"I cannot be the man I need to be and not tell the truth," Tad Cummins told a judge in federal court Thursday Former Tennessee high school teacher Tad Cummins pleaded guilty to kidnapping his then ...