While it can be helpful for learners to begin with the linear presentation of how stretches of DNA form genes, this ...

This study reveals the step-wise establishment of nuclear speckle-associated domains (SPADs) during mouse embryogenesis.

They also made serial genomic deletions and inversions that impact the integrity of the HoxD chromatin domain and also cause remodeling of long-range regulatory elements.

Conclusions SARS-CoV-2 infection markedly restructured 3D host chromatin, featuring widespread compartment A weakening and A–B mixing and global reduction in intra-TAD chromatin contacts.

"When the proteins that determine TAD boundaries - and thus are critical for the chromatin architecture - are disrupted, this can result in distinct developmental disorders and cancer", says ...

They also made serial genomic deletions and inversions that impact the integrity of the HoxD chromatin domain and also cause remodeling of long-range regulatory elements.

To understand the basis of reduced intra-TAD interactions, they assessed chromatin binding of two main TAD organizers, namely CTCF and cohesion.