During a live event, Mark J. Fesler, MD, and participants discuss next steps for a 68-year-old patient with intermediate-risk ...

Munich, Germany – April 9, 2025-- Ebenbuild, a company developing personalized, AI-enabled digital twins of lungs to support clinical decisions and digital clinical trials, today announced its ...

Department of Urology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China Background: Bladder pain syndrome/Interstitial cystitis (BPS/IC) is a chronic urological disorder ...

In MASLD and MASH, TGF-β signaling contributes to hepatocyte lipid accumulation, cell death and fibrosis progression through both Smad and non-Smad pathways. In HCC, TGF-β and other TGF-β-SF cytokines ...

State Key Laboratory of Anti-Infective Drug Discovery and Development, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China ...

including CTGF/CCN2 and WISP1/CCN4, on multiple cell types contributing to the fibrotic pathology. This approach is an evolution from blocking individual CCN proteins and their upstream activator, TGF ...

For instance, the team discovered that non-cancerous cells bordering cancer cells were in a unique state driven by transforming growth factor-beta (TGF-β) signaling, a critical pathway involved ...

What is the significance of the PDE4B pathway in the pathogenesis of IPF and PPF? What has the data demonstrated with nerandomilast so far, and what future data is needed for this therapy? How do you ...

Cardiac fibrosis, a hallmark of heart failure and various ... polarization toward a pro-fibrotic phenotype through enhanced TGF-β1 signaling. The causative role of this pathway was confirmed when ...