Kidney fibrosis, a common endpoint of chronic kidney disease (CKD), is strongly linked to aging, with cellular senescence ...

This study aimed to elucidate the regulation of NAFLD-related liver fibrosis induced by HO-1 through the SIRT1/TGF-ß/Smad3 pathway. HO-1 induction and inhibition were established in C57BL/6J mice ...

The Wnt signaling pathway plays a key role in the development of hepatic fibrosis associated with AE infection. Its activation is positively correlated with EMT and the increased expression of ...

The abnormal expression of metalloproteinases and CTGF in extracellular matrix is ... 4.3 Traditional Chinese Medicine compound targeting the TGF-β/Smad signaling pathway to prevent and treat renal ...

Department of Respiratory Medicine, The First Affiliated Hospital, Hainan Medical University, Longhua, Haikou 570102, P. R. China Hainan Province Clinical Medical Center of Respiratory Disease, ...

MicroRNA-29b inhibits endometrial fibrosis by regulating the Sp1-TGF-beta1/Smad-CTGF axis in a rat model ... and CCN2 in intrauterine adhesions involves the NF-kappaB signaling pathway. PLoS One 2015; ...

amc.uva.nl Introduction In proliferative diabetic retinopathy (PDR), vascular endothelial growth factor (VEGF) and connective tissue growth factor (CTGF) may cause blindness by neovascularisation ...

The STAT3 activator colivelin was introduced to verify the role of the STAT3/NLRP3 signaling pathway in ferroptosis ... Hirudin ameliorates renal interstitial fibrosis via regulating TGF-β1/Smad and ...

Panelists discuss how investigational therapies beyond Janus kinase (JAK) inhibition, including epigenetic modulation, telomerase inhibition, PI3K/AKT/mTOR pathway inhibition, immune modulation, TGF-β ...

Increased TGF-β1 promotes the phosphorylation and nuclear translocation of Smad2/3, sequentially activating the transcription ...