Several factors that induce fibrosis have been identified ... Figure 1: Interactions between CTGF, EGF, PDGF and the profibrotic TGF-β pathway. The fully humanized monoclonal antibody FG-3019 ...

Some of the major conserved molecular processes involve TGF-β, PDGF, CTGF, vasoactive compounds ... matrix signaling pathways. The fact that tissue fibrosis is remarkably plastic suggests ...

Multi-omics analysis of human kidney PDGFRβ+ mesenchymal cells quantified over 14,000 biomolecules across 8 time points, ...

"Letrozole ameliorated MCD- and CCl4-induced liver fibrosis by suppressing the Yap-Ctgf pathway by partially modifying the expressions of Hsd17b13 and Cyp26a1, which reduced retinoic acid level in ...

“Letrozole ameliorated MCD- and CCl4-induced liver fibrosis by suppressing the Yap-Ctgf pathway by partially modifying the expressions of Hsd17b13 and Cyp26a1, which reduced retinoic acid level ...

In the liver, TGF-β signaling is involved in maintaining liver homeostasis and responding to injury by modulating inflammation and fibrosis. HIPPO Pathway: The HIPPO pathway is a kinase cascade ...

These processes are regulated by the cytokines TGF ... connective tissue growth factor (CTGF) in serum might provide information on fibrogenic activity. The extension of pathogenetic concepts of ...

PMD include various oral mucosal diseases such as leukoplakia, erythroplakia, oral submucous fibrosis (OSMF), oral lichen ... mechanism involved in EMT by cross-talk between TGF-β and Wnt/β-catenin ...

This study aimed to elucidate the regulation of NAFLD-related liver fibrosis induced by HO-1 through the SIRT1/TGF-ß/Smad3 pathway. HO-1 induction and inhibition were established in C57BL/6J mice ...

Targeting the IL-11 receptor represents a potential new pathway ... fibrosis and blocking its activity has the potential to be more effective than targeting other factors such as TGF-β and CTGF.

Indeed, gene expression in healthy cells, compared with cystic fibrosis cells, shows an imbalance between two cell signaling pathways: the TGF-β pathway is hyperactivated, while the Wnt pathway ...