Lentiviral transduction is a popular delivery platform for applications such as CAR-T cell engineering or CRISPR-Cas9 gene editing, as it can transduce both dividing and non-dividing cells and ...

This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study seeks to link this finding to regulation of the mitotic surveillance pathway and paclitaxel ...

University of Innsbruck's quantum physicists Francesca Ferlaino and Hans Briegel and biochemist Kathrin Thedieck each receive an ERC Advanced Grant ...

Sickle cell disease (SCD) altered CD8+ T-cell chromatin architecture, triggering ferroptosis and weakening antitumor immunity ...

Manufacturing CAR T cells in the laboratory is expensive and time-consuming. An in vivo approach could get the powerful ...

B-cell acute lymphoblastic leukemia (B-ALL) is the most common cancer in children, accounting for around 85% of pediatric ...

Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg have identified a previously undocumented, organ-specific ...

Researchers at the National University of Singapore (NUS) have developed a scalable, non-viral technology that efficiently ...

Limiting dietary L-Leu intake is a promising strategy to avoid SLC7A5-mediated allogenic T cell expansion and aGVHD while ...

A pair of recent studies from the laboratory of Bin Zhang, MD, Ph.D., the Johanna Dobe Professor of Cancer Immunology, have ...