By targeting surface markers on cancer cells, engineered synthetic receptors expressed on immune cells can be directed to ...

LATS1/2-inactivation and consequent nuclear YAP/TAZ hyperactivation in the mammary epithelium drives the development of a pro ...

This important study focused on characterizing clonally derived MSC populations from the synovium of normal and osteoarthritis (OA) patients, demonstrating their potential to regenerate cartilage in ...

Stationed within the meninges, squads of immune cells lie in wait, ready to unleash an inflammatory assault within the brain if needed. Holding these trigger-happy troops back during peacetime falls ...

Xfinity and Metro by T-Mobile users who have gotten the device already are simply unable to activate them as it seems the carriers haven't updated the network software to support the phones.

Since the precursor frequency of naïve T cells is extremely low, investigating the early steps of antigen-specific T cell activation is challenging ... splenic or thymic single-cell suspensions for ...

Citrus (Cluster Identification, Characterization, and Regression) is an unsupervised analysis tool designed for identifying and stratifying cell subpopulations in multicolor flow cytometry ... T cells ...

and CD4 + and CD8 + T cell activation markers (CD38 and HLA-DR) were measured via flow cytometry. This study provides insights into the biological mechanisms underlying incomplete immune ...

Copyright: © 2025 Elsevier Ltd. Published by Elsevier Ltd. CAR T-cell therapies have revolutionised treatment of many diseases, but their expense means many patients ...

Oncolytic adenoviruses were designed to reach potent intratumoral T-cell activation via expression of bifunctional-T-cell engagers (MATEs). MATEs consist of a CD3 binding domain to bind T cells and a ...