Synthetic lethality is a concept in cancer research that refers to a situation where the simultaneous inactivation of two genes leads to cell death, while the inactivation of either gene alone ...

"It is our great pleasure to share with you the successful approval of Senaparib for the Chinese market, which is another strong proof of the excellence of IMPACT's in-house synthetic lethality R ...

IMPACT Therapeutics (IMPACT), a biopharmaceutical company focusing on the discovery and development of targeted anti-cancer therapeutics based on synthetic lethality, announced that Senaparib capsules ...

Ideaya Biosciences ( ($IDYA) ) has released its Q4 earnings. Here is a breakdown of the information Ideaya Biosciences presented to its investors.

Researchers from Tango Therapeutics Inc. have unveiled DNA ligase 1 (LIG1) as a potential new therapeutic target for synthetic lethality in BRCA1-mutant cancers after CRISPR/Cas9 screening.

RNAi as a tool for functional genomics & identification of synthetic lethal interactions RNAi is the mechanism whereby introduction of dsRNA into a cell results in the degradation of a mRNA ...

Tumor development is an evolutionary process driven by an accumulation of mutations allowing cells to acquire traits that can ultimately lead to a cancerous state. [1] As a consequence cancer is ...

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License . Synthetic lethality approaches in BRCA1/2-mutated cancers have focused on ...

Beyond demonstrating the efficacy of YJ1206, our work underscores the potential of precision medicine approaches that exploit synthetic lethality and pathway vulnerabilities. The promising preclinical ...

There's only one realistic way to at least slow down the crisis. Persuade Americans to not take illicit drugs and help those ...