The main objective of this article is to explain synthesis flow and post-synthesis netlist quality checks. In ASIC flow, synthesis is the part of the front-end design, while the back-end design takes ...

He believed that synthetic nucleic acids—known as oligonucleotides (oligos)—would one day revolutionize modern biology and genetics and would likewise transform medical diagnostics to create ...

According to the company, the therapy comprises a phosphorodiamidate morpholino oligomer, which is conjugated to a fragment antibody that attaches to the transferrin receptor 1, facilitating the ...

DYNE-251 consists of a phosphorodiamidate morpholino oligomer (PMO) conjugated to a fragment antibody (Fab) that binds to the transferrin receptor 1 (TfR1), which is highly expressed on muscle.

DYNE-251 consists of a phosphorodiamidate morpholino oligomer (PMO) conjugated to a fragment antibody (Fab) that binds to the transferrin receptor 1 (TfR1), which is highly expressed on muscle. It is ...

The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/jacs.5c00855.

Consequently, the catalytic atroposelective synthesis of enantiopure atropisomers has garnered considerable attention. A variety of synthetic strategies involving metal catalysis or organocatalysis ...

This study provides fundamental insights into the regulation of a retained intron in the mRNA coding for OGT, a process known to be regulated by the O-GlcNAc cycling system, and highlights the ...