When Supernatural premiered in 2005, few anticipated it would evolve into the longest-running American fantasy series, spanning 15 seasons and over 300 episodes.

In honor of Supernatural coming to an end after 15 seasons, TV Guide presents Winchester Week, a celebration of Sam, Dean, and the entire SPN Family. Find out how the stars feel about saying ...

The nearly season-long, emotionally-charged struggle between good and evil fought by both brothers Sam and Dean, ended up as it has so many times on Supernatural: the guys were betrayed by gals.

Supernatural made a lasting impression with its long run of eerie hunts and emotional storylines. But even a show with such strong character roots isn't immune to the occasional mishap.