Researchers at The Wistar Institute have identified a previously unknown mechanism by which viruses can reprogram ...

Despite substantial medical advancements that have transformed HIV into a manageable chronic condition for individuals, the ...

This manuscript introduces a useful protein-stability-based fitness model for simulating protein evolution and unifying non-neutral models of molecular evolution with phylogenetic models. The model is ...

INSTIs block integrase, an enzyme that HIV uses to put HIV DNA into human DNA inside the CD4 T cells. INSTIs belong to a category of drugs known as integrase inhibitors. INSTIs are well ...

A genetic mutation that helps protect against HIV infection has been traced back to a single individual who lived near the ...

The discovery of recombinant DNA proved that biology, not chemistry alone, could create new medicines like life-saving ...

Misconceptions about these vaccines stem from misunderstandings about how the immune system and vaccines work. So do they ...

Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, United States Divisions of Human Biology and Basic Sciences, Fred Hutchinson Cancer Center, Seattle, United States ...

to show how structure–function relationships of Env proteins can inform the design of an effective HIV-1 vaccine. With special emphasis on the variable regions of gp120, we highlight the ...

Around 1.1 million people are living with HIV in the United States of America (USA). Nearly one in seven of these people are unaware they have HIV. The size of the HIV epidemic is relatively small ...

"This region sits right at the lipid bilayer—or membrane—on the HIV cells," says first author ... the team mapped to atomic-level detail. "The structure of the antibody itself holds an ...

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, San Diego, California 92093, United States ...